The Zacherlhaus is a residential and business building designed by Joze Plecnik and built in the 1st district of Vienna, the Innere Stadt. The construction was commissioned by Johann Evangelist Zacherl, son of the industrial magnate Johann Zacherl, who built the Zacherlfabrik. It was one of the first modern buildings erected at the Wildpretmarkt in Vienna's city centre. The facade is made of polished grey granite plates. The figure of Archangel Michael on the facade is the work of Ferdinand Andri, while the caryatids were made by Franz Metzner. The oval-shaped stairwell features a lamp that resembles an insect; this is a reference to insecticide, the production of which had made the Zacherl family rich. In 1949, it was necessary to restore the Zacherlhaus after it had been damaged during World War II.

Today, the Zacherlhaus is a listed building. It is one of the most important examples of the work of the Otto Wagner school.