Miladin Prljevic was born in Uzice, where he completed first two years of high school and then finished it in Skopje. He moved back to Belgrade with his family in 1924 where he graduated from the Department of Architecture Faculty of Engineering and after worked for several years in Montenegro. He emphasized the importance of collective architecture. After the Second World War was the initiator and founder of the Institute for the Study of residential architecture until his death in 1973.

Unlike his contemporaries, Prljevic intensively experimented with form, fostering a distinctive visual expression. During this period, he made dozens of projects and created his most important architectural achievement Palace Albania (1939). In addition to the Palace Albania, among his most significant buildings, are houses Djordje Zdravkovic in Belgrade. Many of his architectural ideas are not achieved, such as the museum complex on Tasmajdan, Clinic for treatment of tuberculosis and sanatorium at Avala, Exchange Building, District Insurance Office workers in Belgrade. For these projects he won the first prize, but because of lack of money, they are not implemented. He also designed buildings in Cetinje, Podgorica, Niksic, Brcko, Split, Novi Sad, Sremska Mitrovica, Nis, Kraljevo, Bor, Loznica, Cacak, Obrenovac, Uzice, Pozegi, Zlatibor and Tara.